Loneliness and Social Isolation Are Linked to Faster Biological Aging

Moderate Evidence·Journal of affective disorders·Mar 2026

Being lonely or socially isolated is associated with measurably faster biological aging. Across over 340,000 UK Biobank participants and 6,300 NHANES participants, higher loneliness and isolation scores correlated with accelerated aging on multiple biomarker clocks. The effect was consistent across three different ways of measuring biological age. Faster biological aging also appeared to partly explain how loneliness connects to earlier death.

Key Insight

This study suggests social connection may be relevant to slowing biological aging.

Original Paper

Journal of affective disorders··334,415 UK Biobank adults and 6,364 NHANES adults

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