Skip to content
Journal ArticleAging cell·Jul 2026

NR May Slow Muscle Aging Clocks While Hard Interval Training Speeds Some Up

Key Insight

This study suggests NR and HIIT may affect muscle epigenetic aging clocks in opposite ways.


Nicotinamide riboside, a popular NAD+ booster, was linked to slower epigenetic aging in muscle across several aging clocks. Surprisingly, high-intensity interval training pushed some of those clocks in the opposite direction, appearing to speed up the pace of aging. The two interventions worked against each other on these markers, which is unexpected and needs more study.

Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.