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Journal ArticleEBioMedicine·Jun 2026

High-Dose DHA Reaches the Brain but Didn't Boost Memory in 2 Years

Key Insight

This study suggests high-dose DHA reaches the brain but may not improve memory in at-risk older adults.


Omega-3 DHA is a popular pick for brain health, especially for people at risk of dementia. This two-year trial gave older adults with low omega-3 intake high-dose DHA. The DHA clearly made it into their brain fluid, even in those carrying the high-risk APOE ε4 gene. But there was no difference in memory, thinking, or brain size compared to placebo.

Conflict of Interest Disclosure: One author reports grants from and consulting fees for many drug companies, including Eisai, Roche, and Novo Nordisk, outside this work.

Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.