Eight Hyped Compounds Failed to Extend Lifespan in a Major Mouse Study
This study suggests that dose and timing matter enormously, and early lifespan results in mice often don't hold up.
The NIA's Interventions Testing Program tested eight compounds across three lab sites in genetically diverse mice. None extended lifespan. That includes astaxanthin, alpha-ketoglutarate, pioglitazone, atorvastatin-telmisartan, and others with prior promising results. Some compounds previously shown to work at different doses or start ages didn't replicate under new conditions. Two drugs actually shortened lifespan in female mice.
Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.
Related Studies
All researchJust 5,700 Daily Steps Cut Death Risk By 13% In Older Adults
Looking at dozens of studies with over 367,000 older adults, regular walking was tied to lower risk of death, disease, and cognitive…
Quail Bred to Reproduce More Aged Faster, Supporting a Core Theory of Aging
Researchers selectively bred Japanese quail for higher or lower reproductive effort across several generations.
We May Not Be Aging Slower. We're Just Starting Later.
A big question in longevity research is whether rising life expectancy means we're actually aging more slowly.