Yamanaka factors
DEYamanaka-Faktoren
The Yamanaka factors are four transcription factors, OCT4, SOX2, KLF4, and c-MYC (OSKM), identified by Shinya Yamanaka in 2006 as sufficient to reprogram differentiated somatic cells back into a pluripotent embryonic-like state. This discovery, awarded the 2012 Nobel Prize, demonstrated that cellular identity and aging are reversible. They are now central tools in regenerative medicine, disease modeling, and longevity research focused on epigenetic rejuvenation.