Mitochondrial biogenesis
DEMitochondriale Biogenese
Mitochondrial biogenesis is the process by which cells increase mitochondrial mass and capacity by coordinating the expression of nuclear and mitochondrial genes. The transcriptional coactivator PGC-1-alpha is a key nodal regulator, regulated by AMPK and SIRT1 among other signals. Endurance exercise, caloric restriction, and cold exposure are well-established physiological stimuli, and robust biogenesis is associated with muscular endurance, metabolic flexibility, and healthy aging.
Sources
- Mootha VK, Lindgren CM, Eriksson KF, et al.. (2003). PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. *Nature Genetics*doi:10.1038/ng1180
- Scarpulla RC. (2008). Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function. *Physiological Reviews*doi:10.1152/physrev.00025.2007