Insulin sensitivity

Insulin sensitivity describes how effectively cells, especially in muscle, liver, and adipose tissue, respond to insulin to take up glucose and suppress hepatic glucose output. Higher sensitivity allows lower circulating insulin to maintain normoglycemia, reducing strain on pancreatic beta cells. It is improved by physical activity, sleep, low visceral fat, and dietary fiber. Robust insulin sensitivity is a hallmark of metabolic health and longevity-relevant resilience.