Fisetin

Fisetin is a flavonoid found in strawberries, apples, and persimmons. In aged mice, Yousefzadeh et al. (2018, EBioMedicine) reported reduced senescent cell burden and extended median lifespan using a late-life intermittent dosing protocol; the paper also documented reduced age-associated tissue dysfunction. The NIA Interventions Testing Program (Harrison et al., 2023, GeroScience) tested fisetin in genetically heterogeneous (UM-HET3) mice and did not replicate the lifespan extension in either sex; early human trials have likewise not yet demonstrated senescent-cell clearance, so the senolytic claim should be considered unconfirmed in rigorous models. Mechanisms include induction of apoptosis in senescent cells and modulation of inflammatory pathways, making it a candidate dietary senolytic under investigation. Human trials are ongoing, and clinical evidence in people remains preliminary.