NAD+ and inflammation
2 papers in the library, strongest Moderate.
Graded Moderate · Narrative review pulling together mechanistic and largely preclinical work on mitochondrial aging, with the proposed rejuvenation strategies not yet tested in people.
Papers 2
- Why Your Mitochondria May Be Driving Aging and Chronic InflammationModerate2026npj agingScientists are zeroing in on mitochondria (the energy factories in your cells) as a main driver of aging, not just a casualty of it. When they break down, they leak signals that trigger chronic, low-grade inflammation and exhaust stem cells. This review highlights NAD+ depletion as a key bottleneck and looks at fixes like NAD+ boosters and mitophagy enhancers.
- NMN Calmed Eye Inflammation and Slowed Blood Vessel Damage in MicePreliminaryn = 572026Investigative ophthalmology & visual scienceWet macular degeneration happens when abnormal blood vessels grow under the retina and scar tissue forms. In mice with laser-induced damage mimicking this, NMN shrank the abnormal vessel growth and cut inflammation. It also reduced the scarring that drives late-stage vision loss. This is early animal work, so it says nothing yet about NMN supplements and human eyesight.
How this map is computed
A mark's size is the number of papers we hold on that pairing. It is a count, not a weighting by study design or sample size.
The fill shows the strongest grade in the cell. One Strong paper among four Preliminary ones still fills it dark, so open the cell to see the rest.
Grades and verdicts are assigned by a named person, never by counting.
An empty cell is a finding: nobody in our library has run that trial yet.