35 Studien
Forschungsbibliothek
Peer-reviewed Papers aus Top-Journals, zusammengefasst und nach Evidenzstärke bewertet. Updates jeden Mo, Mi & Fr.
NMN Plus Apigenin May Protect Aging Muscle and Bone Better Together
In aged mice, combining the NAD booster NMN with apigenin (a compound found in parsley and chamomile) reduced cartilage breakdown, bone loss, and muscle wasting. The combo works by both producing more NAD+ and blocking enzymes that consume it. Treated mice also showed better exercise capacity. The benefits appeared to work through SIRT3 activation and changes in gut bacteria that produce a helpful fat molecule.
Centenarians Show a Distinct Metabolic Profile Tied to Bile Acids and NAD+
People who live past 100 have a unique metabolic fingerprint. In a study of 213 participants from the New England Centenarian Study, extremely long-lived individuals had higher levels of certain bile acids and lower levels of bilirubin compared to younger controls. Higher bile acid and steroid levels were linked to lower mortality risk. The researchers also built a "metabolomic clock" that estimates biological age, and deviations from it predicted death risk.
A Newly Found Enzyme Breaks Down NAD+ Inside Mitochondria
Scientists identified a mitochondrial enzyme called SelO that breaks NAD+ into NMN and AMP. This reaction ramps up when mitochondria are working hard, essentially acting as a brake to prevent metabolic overload. It also plays a direct role in fat burning by linking up with fat oxidation enzymes. The mechanism is conserved from bacteria to mammals, suggesting it's been essential for a very long time.
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