Caloric Restriction Slows Aging Most in the Heart and Metabolism
Cutting calories doesn't slow aging evenly across all organs. In a two-year trial, 185 adults were randomly assigned to caloric restriction or normal eating. The caloric restriction group aged about one year less in their cardiovascular and metabolic systems over 24 months. Kidney aging, however, didn't budge, and liver aging only slowed modestly at the two-year mark.
Kernaussage
This study suggests caloric restriction may preferentially protect cardiovascular and metabolic health.
Originalstudie
Verwandte Studien
Tracking Your 'Biological Age' Over Time May Predict Death Risk Better Than a Single Snapshot
In over 90,000 Dutch adults followed for nearly 14 years, people whose biological age ran ahead of their calendar age had a higher risk of dying. More importantly, among 25,000 people measured twice, those whose biological age sped up over time faced even greater risk. People stuck in a pattern of accelerated aging had a 39% higher mortality risk compared to those aging at a normal pace. The results suggest that checking biological age once might not be enough.
Faster Biological Aging Linked to Worsening Brain Small Vessel Disease
People who age faster biologically (based on blood biomarkers) appear more likely to develop worsening brain small vessel disease. In roughly 3,000 middle-aged adults followed for about five years, those with higher biological age scores had more new tiny brain lesions like lacunes and microbleeds. This held true even after accounting for actual calendar age. The finding suggests that biological aging clocks could help flag people at risk for this common precursor to dementia and stroke.
Frailty verdoppelt das Sterberisiko bei Herz- und Stoffwechselerkrankungen
In fünf großen Studien aus den USA, Großbritannien und China hatten Menschen mit Herz- oder Stoffwechselerkrankungen, die frail waren, ein bis zu 132% höheres Risiko, an irgendeiner Ursache zu sterben. Selbst leichte Schwäche (pre-frail) erhöhte das Risiko um 21% bis 66%. Der Zusammenhang war am stärksten bei Menschen unter 65 und mit niedrigerem Körpergewicht.
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