# Senolytics Plus TB Drugs Boost Survival in Infected Mice

*Elimination of senescent cells with senolytic drugs as adjunctive host-directed therapy reduces tuberculosis progression in mice.*

- **Evidence Level**: Preliminary
- **Publication Types**: Journal Article
- **Journal**: Nature communications
- **Sample Size**: Mice (young and aged, plus a susceptible strain)
- **Authors**: Shee S, Martinez-Martinez YB, Koleske B, Shaku MT, Yabaji S, Kobzik L, Kramnik I, Bishai W
- **Published**: 2026-05-07
- **Topics**: senolytics, tuberculosis, cellular senescence
- **DOI**: https://doi.org/10.1038/s41467-026-72874-y
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42098153/

## Summary

Tuberculosis triggers some lung cells to become senescent (zombie-like cells that won't die but cause damage). Researchers gave infected mice a senolytic cocktail of dasatinib, quercetin, and fisetin alongside standard TB treatment. The combo improved survival and reduced lung damage, especially in older mice.

## Practical Takeaway

This study suggests senolytic drugs may warrant testing as add-on therapy for tuberculosis in humans.

---

_Canonical: https://longevity-china.com/en/research/senolytics-plus-tb-drugs-boost-survival-in-infected-mice · Part of Longevity Cities · Updated 2026-05-07_