# Regular Exercise May Rewind the Molecular Clock in Aging Muscle

*Delayed molecular aging, preservation of energy metabolism and enhanced exercise response in exercise-trained human muscle.*

- **Evidence Level**: Moderate
- **Publication Types**: Journal Article
- **Journal**: Nature aging
- **Sample Size**: Young and older adults with differing fitness levels
- **Authors**: Janssens GE, Trętowicz MM, Grevendonk L, Kotte M, Scantlebery A, Schomakers BV, van Weeghel M, Hermans J, Vervaart MAT, Wever EJM, Denis SW, Jongejan A, Salomons GS, Vaz FM, Schrauwen P, Hoeks J, Houtkooper RH
- **Published**: 2026-07-03
- **Topics**: exercise, muscle aging, NAD+
- **DOI**: https://doi.org/10.1038/s43587-026-01150-x
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42399371/

## Summary

In older adults, muscle showed lower activity in genes tied to energy production compared to younger people. But in older adults who trained regularly, half of those aging changes were gone. Their muscle looked more like young muscle at the molecular level.

## Practical Takeaway

This study suggests sustained physical training may keep aging muscle more youthful.

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_Canonical: https://longevity-china.com/en/research/regular-exercise-may-rewind-the-molecular-clock-in-aging-muscle · Part of Longevity Cities · Updated 2026-07-03_