# Nicotinamide Riboside Protected Mitochondria in Mice With a Rare Muscle Disease

*Nicotinamide riboside prevents mitochondrial dysfunction in nemaline myopathy type 6.*

- **Evidence Level**: Preliminary
- **Publication Types**: Journal Article
- **Journal**: Human molecular genetics
- **Sample Size**: NEM6 knockin mice (number not specified)
- **Authors**: Baelde RJ, Vonk LA, Nollet EE, Galli RA, Monteiro AF, Bastu S, Das B, van Weeghel M, Schomakers BV, Vinten KT, van den Berg M, van der Velden J, Houtkooper RH, Voermans NC, Malfatti E, Ottenheijm CAC, de Winter JM
- **Published**: 2026-06-12
- **Topics**: nicotinamide riboside, NAD+, mitochondria
- **DOI**: https://doi.org/10.1093/hmg/ddag023
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42323895/

## Summary

NR, a popular NAD+ booster, kept muscle cell powerhouses working in mice with a rare genetic muscle disorder. The disease drains NAD+ levels and damages how muscles make energy. Starting NR early stopped this damage from setting in. This is early animal work tied to a specific inherited condition, not healthy people.

## Practical Takeaway

This early animal study supports NR's role in supporting NAD+ levels and muscle mitochondria.

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_Canonical: https://longevity-china.com/en/research/nicotinamide-riboside-protected-mitochondria-in-mice-with-a-rare-muscle-disease · Part of Longevity Cities · Updated 2026-06-12_