# New Aging Clocks Reveal Blood Clotting Factors May Drive Organ Decline

*Multimodal clocks of human aging.*

- **Evidence Level**: Moderate
- **Publication Types**: Journal Article
- **Journal**: Cell
- **Sample Size**: 2,019 Chinese adults aged 18-91
- **Authors**: Li J, Jiang B, Zhang W, Hao J, Liu Z, Ji Q, Zheng Y, Lu X, Zheng Z, Ma S, Fan Y, Gao DD, Hou XW, Li J, Tang J, Jing Y, Geng L, Wu R, Zhang B, Sun S, Cai Y, Yan K, Xiong M, Dong C, Ma X, Xu G, Ji Z, Yan H, Zheng Q, Huang H, Zhang L, Li J, Jiang M, Xu LJ, Chen Y, Qu G, Lei W, Wang H, Ping J, Zhou J, Yi M, Jiang M, Jing Y, Ye WD, Zhang X, Chu X, He Y, Zhao Q, Wu Q, He M, Ma L, Liu P, Zhao L, Zhai QC, Qin J, Lu J, Yang X, Zhang S, Xiong Y, Ren H, Yang W, Huang Z, Zhang J, Zhang M, Chen P, Dong J, Zhang Y, Yan T, Ye JL, Huang P, Qi Z, Liu Y, Shuai J, Chen CS, Li P, Li D, Xu X, Song X, Li J, Ping J, Hu J, Sun X, Ai J, Wang Z, Zhang Y, Yang P, Ning T, Yu Y, He Z, Zhang H, Zhang T, Yang Y, Wang Q, Lin F, Jin X, Chen X, Ren J, Song M, Wang S, Yang J, Li J, Song W, He F, Yang YG, Pei G, Qu J, Zhang W, Pu J, Zhang F, Zhao G, Zhang W, Liu GH
- **Published**: 2026-05-08
- **Topics**: biomarkers, aging clocks, inflammation
- **DOI**: https://doi.org/10.1016/j.cell.2026.04.025
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42105758/

## Summary

Researchers built a multi-layered aging clock using clinical, physiological, and molecular data from over 2,000 Chinese adults. They found that plasma proteins can predict both your age and how well your body is holding up. The standout discovery: clotting factors pile up with age and may fuel organ-wide aging and inflammation.

## Practical Takeaway

This research points to blood-based protein tests as a promising way to track biological age in the future.

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_Canonical: https://longevity-china.com/en/research/new-aging-clocks-reveal-blood-clotting-factors-may-drive-organ-decline · Part of Longevity Cities · Updated 2026-05-08_