# NAD Sprayed Up the Nose Helped Mice Regrow Their Sense of Smell

*Therapeutic effect of intranasal nicotinamide adenine dinucleotide in the restoration of olfactory dysfunction.*

- **Evidence Level**: Preliminary
- **Publication Types**: Journal Article
- **Journal**: Experimental & molecular medicine
- **Sample Size**: Mice with induced smell loss and lab-grown human olfactory stem cells
- **Authors**: Yoo SH, Jang JY, Bae JS, Ventura R, Kim EH, Kim AY, Mo JH, Park J, Kang K, Yun Y, Lee JH, Kim YJ, Lee DJ, Kim JH
- **Published**: 2026-07-01
- **Topics**: NAD+, smell loss, regeneration
- **DOI**: https://doi.org/10.1038/s12276-026-01761-9
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42380286/

## Summary

A form of NAD delivered through the nose helped restore lost smell in mice and pushed stem cells to become new smell neurons. For anyone who lost their sense of smell after COVID, this hints at a possible future treatment. But this was tested in mice and lab-grown human cells, not in people yet. It's early days, so don't expect a nasal NAD spray at the pharmacy soon.

## Practical Takeaway

This early animal work hints NAD might one day help restore lost smell, but human proof is missing.

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_Canonical: https://longevity-china.com/en/research/nad-sprayed-up-the-nose-helped-mice-regrow-their-sense-of-smell · Part of Longevity Cities · Updated 2026-07-01_