# NAD+ Booster Raised Cellular Fuel But Didn't Improve Memory in 12 Weeks

*A phase-II randomized controlled pilot study of nicotinamide riboside supplementation in older adults with amnestic mild cognitive impairment.*

- **Evidence Level**: Moderate
- **Publication Types**: Journal Article, Randomized Controlled Trial, Clinical Trial, Phase II
- **Journal**: Alzheimer's & dementia : the journal of the Alzheimer's Association
- **Sample Size**: 42 older adults with amnestic mild cognitive impairment
- **Authors**: Martens CR, Decker KP, DeConne TM, Sanjana F, Horvat F, Rizzi NA, Awad C, Habash E, Hobson JC, Kramer MK, Armstrong ML, Reisdorph N, Pohlig RT, Lanzi AM, Johnson CL, Cohen ML, Ellison JM
- **Published**: 2026-07-01
- **Topics**: nicotinamide riboside, NAD+, cognition
- **DOI**: https://doi.org/10.1002/alz.71605
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42478598/

## Summary

Nicotinamide riboside, a popular NAD+ supplement, doubled NAD+ levels in older adults with mild memory problems. But it did not improve their thinking, brain blood flow, or blood pressure over 12 weeks. There were hints of more blood flow in the memory region of the brain, but that needs more testing. It was safe and well tolerated.

## Practical Takeaway

This pilot suggests NR raises NAD+ but may not improve memory in mild cognitive impairment.

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