# Aging Blood Stem Cells May Be a Hidden Source of Chronic Inflammation

*Trained immunity links hematopoietic stem cell aging to aging-associated inflammation.*

- **Evidence Level**: Preliminary
- **Publication Types**: Journal Article
- **Journal**: Nature aging
- **Sample Size**: Mice
- **Authors**: Mu WC, Barthez M, Feng Y, Chen Y, Wang CL, Huang JY, Li J, Lanhart P, Tsui C, Kim YJ, Verdin E, Netea MG, Chen D
- **Published**: 2026-07-16
- **Topics**: stem cells, inflammation, SIRT3
- **DOI**: https://doi.org/10.1038/s43587-026-01175-2
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42463951/

## Summary

In mice, the stem cells that make blood become a driver of the constant, low-level inflammation that comes with age. A mitochondrial protein called SIRT3 normally keeps these cells in check, but it fades over time. Boosting SIRT3 in these stem cells reduced inflammation and even improved memory and movement in older mice. This points to the blood-forming system as a possible target for staying healthier longer.

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_Canonical: https://longevity-china.com/en/research/aging-blood-stem-cells-may-be-a-hidden-source-of-chronic-inflammation · Part of Longevity Cities · Updated 2026-07-16_