# Men's Health After 40

For men over 40, the best moves act while the damage is still cheap to stop. Measure ApoB and lipoprotein(a) once to set your cardiovascular strategy, lift weights two to four times a week with roughly 1.0 to 1.2 g protein per kg body weight daily, and protect 7 to 9 hours of sleep. Most testosterone worry is misplaced. Only about 2% of men aged 40 to 79 have genuine late-onset hypogonadism, and real TRT needs two low morning readings plus symptoms, not a single number from a bad week.

Your 40s are the most important decade you'll never get back. Here is what the evidence actually says about heart, hormones, muscle, sleep, and prostate, and what to do with it.

## On this page

- Why your 40s are the decade that decides everything
- Testosterone: what's real and what's just marketing?
- How do you keep your muscle past 40?
- Which heart and metabolic numbers actually matter?
- Sleep, mood, and the PSA question
- How do you build a check-up that's actually useful?

## FAQ

- Should I have my testosterone tested?
- Is testosterone replacement therapy safe?
- Do I really need PSA screening?
- How often should I lift weights at 40+?
- Is beer okay in moderation?
- Is there such a thing as male menopause (Andropause)?
- What's the single most useful thing to do this year?

## Sources

- Wu FC, Tajar A, Beynon JM, Pye SR, Silman AJ, et al. (European Male Aging Study Group). (2010). Identification of Late-Onset Hypogonadism in Middle-Aged and Elderly Men. New England Journal of Medicine. https://doi.org/10.1056/NEJMoa0911101
- Bhasin S, Brito JP, Cunningham GR, Hayes FJ, Hodis HN, et al.. (2018). Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline. Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2018-00229
- Corona G, et al.. (2020). European Academy of Andrology (EAA) clinical practice guidelines on the diagnosis and management of functional hypogonadism in men. Andrology. https://doi.org/10.1111/andr.12770
- Khera M, Torres LO, Grober ED, Morgentaler A, Miner M, Jones TH, Mills JN, Salonia A. (2025). Male hypogonadism: recommendations from the Fifth International Consultation on Sexual Medicine (ICSM 2024). Sexual Medicine Reviews. https://doi.org/10.1093/sxmrev/qeaf036
- Lincoff AM, Bhasin S, Flevaris P, Mitchell LM, Basaria S, et al. (TRAVERSE Study Investigators). (2023). Cardiovascular Safety of Testosterone-Replacement Therapy. New England Journal of Medicine. https://doi.org/10.1056/NEJMoa2215025
- Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, et al. (EWGSOP2). (2019). Sarcopenia: revised European consensus on definition and diagnosis. Age and Ageing. https://doi.org/10.1093/ageing/afy169
- Mach F, Baigent C, Catapano AL, Koskinas KC, Casula M, et al.. (2019). 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. European Heart Journal. https://doi.org/10.1093/eurheartj/ehz455
- Authors/Task Force Members; ESC/EAS. (2025). 2025 Focused Update of the 2019 ESC/EAS Guidelines for the management of dyslipidaemias. European Heart Journal. https://doi.org/10.1093/eurheartj/ehaf190
- Kronenberg F, Mora S, Stroes ESG, Ference BA, Arsenault BJ, et al.. (2022). Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement. European Heart Journal. https://doi.org/10.1093/eurheartj/ehac361
- Hugosson J, Roobol MJ, Månsson M, Tammela TLJ, Zappa M, et al. (ERSPC investigators). (2019). A 16-yr Follow-up of the European Randomized study of Screening for Prostate Cancer. European Urology. https://doi.org/10.1016/j.eururo.2019.02.009
- Wood AM, Kaptoge S, Butterworth AS, Willeit P, Warnakula S, et al.. (2018). Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies. The Lancet. https://doi.org/10.1016/S0140-6736(18)30134-X
- Wilt TJ, Jones KM, Barry MJ, Andriole GL, Culkin D, Wheeler T, Aronson WJ, Brawer MK. (2017). Follow-up of Prostatectomy versus Observation for Early Prostate Cancer (PIVOT). New England Journal of Medicine. https://doi.org/10.1056/NEJMoa1615869
- Hu JC, O'Malley P, Chughtai B, Isaacs A, Mao J, Wright JD, Hershman D, Sedrakyan A. (2017). Comparative Effectiveness of Cancer Control and Survival after Robot-Assisted versus Open Radical Prostatectomy. The Journal of Urology. https://doi.org/10.1016/j.juro.2016.09.115

_Full guide: https://longevity-china.com/en/guide/men-40-plus_

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_Canonical: https://longevity-china.com/en/guide/men-40-plus · Part of Longevity Cities · Updated 2026-06-22_