# Longevity Protein Klotho May Protect Against Cognitive Decline in Parkinson's

- **Evidence Level**: Preliminary
- **Journal**: The Journal of neuroscience : the official journal of the Society for Neuroscience
- **Sample Size**: Two independent human PD cohorts (size not specified) plus transgenic mouse models
- **Published**: 2026-03-31
- **Topics**: Parkinson's, klotho, cognition
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/41916755/

## Summary

People with Parkinson's disease who carry a specific variant of the klotho gene tended to perform better on executive thinking tasks across two separate groups. In mice engineered to model Parkinson's, boosting klotho levels improved brain function and reduced alpha-synuclein (a toxic protein that builds up in Parkinson's). The cognitive benefits showed up without improving motor symptoms. Lab experiments suggested klotho may work by helping brain cells clear that toxic protein more effectively.

## Practical Takeaway

This study suggests klotho-related therapies could one day target cognitive decline in Parkinson's.

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_Canonical: https://longevity-china.com/de/research/longevity-protein-klotho-may-protect-against-cognitive-decline-in-parkinson-s · Part of Longevity Cities · Updated 2026-03-31_