# Anti-Aging-Supplements: Was wirkt

Die meisten Supplements verlängern dein Leben nicht messbar. Eine kleine Tier-1-Gruppe lohnt sich aber, um echte Mängel auszugleichen oder gesundes Altern zu stützen, sobald die Basics sitzen: Vitamin D, Omega-3, Magnesium und Kreatin, grob 40 bis 65 € pro Monat in DACH. Nichts davon schlägt Bewegung, Ernährung, Schlaf und Stressmanagement. Teste erst deine Blutwerte (25-OH Vitamin D, Omega-3-Index, Ferritin, B12) und füll dann gezielt die Lücke auf, statt zu raten.

Was die Wissenschaft wirklich über Nahrungsergänzung fürs Altern sagt

## On this page

- Supplements vs. Lebensstil
- NAD+-Booster: Lohnen sich NMN und NR?
- Vitamin D: Wie viel brauchst du wirklich?
- Omega-3-Fettsäuren: Wie viel EPA und DHA brauchst du?
- Welche weiteren Supplements solltest du kennen?
- Was man vermeiden sollte

## FAQ

- Was ist das beste einzelne Longevity-Supplement zum Anfangen?
- Sind Longevity-Supplements langfristig sicher?
- Wie viel sollte ich für Supplements ausgeben?
- Können Supplements mit Medikamenten interagieren?

## Sources

- Pacholec M, Bleasdale JE, Chrunyk B, et al.. (2010). SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.M109.088682
- Yousefzadeh MJ, Zhu Y, McGowan SJ, et al.. (2018). Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. https://doi.org/10.1016/j.ebiom.2018.09.015
- Zhu Y, Tchkonia T, Pirtskhalava T, et al.. (2015). The Achilles' heel of senescent cells: from transcriptome to senolytic drugs (D+Q). Aging Cell. https://doi.org/10.1111/acel.12344
- Bhatt DL, Steg PG, Miller M, et al.. (2019). Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia (REDUCE-IT). New England Journal of Medicine. https://doi.org/10.1056/NEJMoa1812792
- Nicholls SJ, Lincoff AM, Garcia M, et al.. (2020). Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events: STRENGTH. JAMA. https://doi.org/10.1001/jama.2020.22258
- Harris WS, Tintle NL, Imamura F, et al.. (2021). Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies (FORCE consortium). Nature Communications. https://doi.org/10.1038/s41467-021-22370-2
- McBurney MI, Tintle NL, Vasan RS, Sala-Vila A, Harris WS. (2021). Using an erythrocyte fatty acid fingerprint to predict risk of all-cause mortality: the Framingham Offspring Cohort. American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqab195
- Zhu H, Manson JE, Cook NR, Bekele BB, Chen L, et al.. (2025). Vitamin D3 and marine ω-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial. American Journal of Clinical Nutrition. https://doi.org/10.1016/j.ajcnut.2025.05.003
- Demay MB, Pittas AG, Bikle DD, et al.. (2024). The 2024 Endocrine Society Clinical Practice Guideline on Vitamin D for the Prevention of Disease. Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/clinem/dgae290
- Nacarelli T, Lau L, Tang Y, et al.. (2019). NAD+ metabolism governs the proinflammatory senescence-associated secretome. Nature Cell Biology. https://doi.org/10.1038/s41556-019-0287-4
- Lv H, Lv G, Chen C, et al.. (2021). NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion. Cell Metabolism. https://doi.org/10.1016/j.cmet.2020.10.021
- Fernandez ME, Bernier M, Price NL, Camandola S, Aon MA, ..., de Cabo R, et al.. (2025). Is taurine an aging biomarker?. Science. https://doi.org/10.1126/science.adl2116
- Marcangeli V, et al.. (2025). Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans. Aging Cell. https://doi.org/10.1111/acel.70191
- López-Lluch G, Del Pozo-Cruz J, Sánchez-Cuesta A, Cortés-Rodríguez AB, Navas P. (2019). Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization. Nutrition. https://doi.org/10.1016/j.nut.2018.05.020
- EFSA NDA Panel. (2026). Safety of β-nicotinamide mononucleotide (NMN) as a novel food. EFSA Journal. https://doi.org/10.2903/j.efsa.2026.10007

_Full guide: https://longevity-china.com/de/guide/longevity-supplements_

---

_Canonical: https://longevity-china.com/de/guide/longevity-supplements · Part of Longevity Cities · Updated 2026-06-22_